Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | BACE1 | P56817 | 6/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1595139 | 0.83 | PPARG (0.45) | PPARGPPARAEPHX2FPR2ACE | |
| SCHEMBL1595140 | 0.83 | PPARG (0.45) | PPARGPPARAEPHX2FPR2ACE | |
| SCHEMBL4297298 | 0.83 | PPARG (0.45) | PPARGPPARAEPHX2FPR2ACE | |
| SCHEMBL4297294 | 0.83 | PPARG (0.45) | PPARGPPARAEPHX2FPR2ACE | |
| SCHEMBL21528786 | 0.81 | MMP2 (0.42) | PPARGPPARAEPHX2BACE1BCHE | |
| SCHEMBL21528784 | 0.81 | MMP2 (0.42) | PPARGPPARAEPHX2BACE1BCHE | |
| SCHEMBL3736419 | 0.78 | PPARG (0.45) | PPARGPPARAEPHX2FPR2ACE | |
| SCHEMBL5440353 | 0.78 | BACE1 (0.62) | BACE1BCHE | |
| SCHEMBL5440357 | 0.78 | BACE1 (0.62) | BACE1BCHE | |
| SCHEMBL5753617 | 0.75 | FFAR2 (0.43) | PPARGPPARAEPHX2FPR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919504-B2 | Thiadiazole modulators of PKB | AMGEN INC. (US) | 2011-04-05 | — | — | US | disclosed |