SCHEMBL21528786

SCHEMBL21528786

CCCC(O)C(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)NC(=O)O

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 1/20 0.42
▸ MMP3 P08254 1/20 0.42
▸ PPARG P37231 3/20 0.42
▸ PPARA Q07869 3/20 0.42
▸ EPHX2 P34913 2/20 0.42
▸ KIFC1 Q9BW19 2/20 0.41
▸ PSEN1 P49768 1/20 0.41
▸ PSEN2 P49810 1/20 0.41
▸ APH1B Q8WW43 1/20 0.41
▸ NCSTN Q92542 1/20 0.41
▸ APH1A Q96BI3 1/20 0.41
▸ PSENEN Q9NZ42 1/20 0.41
▸ FFAR1 O14842 4/20 0.40
▸ PPARD Q03181 2/20 0.39
▸ FPR2 P25090 1/20 0.39
▸ CCR2 P41597 1/20 0.39
▸ TPH1 P17752 1/20 0.39
▸ BCHE P06276 1/20 0.39
▸ BACE1 P56817 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21528784 1.00 MMP2 (0.42) MMP2MMP3PPARGPPARAEPHX2
SCHEMBL21549375 0.85 KLK5 (0.46) MMP2MMP3PPARGPPARAPSEN1
SCHEMBL1594481 0.81 PPARG (0.42) PPARGPPARAEPHX2FFAR1FPR2
SCHEMBL4297294 0.80 PPARG (0.45) PPARGPPARAEPHX2FFAR1FPR2
SCHEMBL4297298 0.80 PPARG (0.45) PPARGPPARAEPHX2FFAR1FPR2
SCHEMBL1595139 0.80 PPARG (0.45) PPARGPPARAEPHX2FFAR1FPR2
SCHEMBL1595140 0.80 PPARG (0.45) PPARGPPARAEPHX2FFAR1FPR2
SCHEMBL26834640 0.80 HDAC3 (0.49) BCHEBACE1
SCHEMBL21528813 0.79 MMP2 (0.50) MMP2MMP3PPARGPPARAEPHX2
SCHEMBL21528815 0.79 MMP2 (0.50) MMP2MMP3PPARGPPARAEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11384060-B2 Amide compounds and use thereof ALPHALA CO., LTD. (TW) 2022-07-12 — — US disclosed
US-20190337915-A1 AMIDE COMPOUNDS AND USE THEREOF ALPHALA CO., LTD. (TW) 2019-11-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190337915-A1 AMIDE COMPOUNDS AND USE THEREOF GLP1R, IAPP, GPR119 MMP2 2087/4885MMP3 3257/4885PPARG 93/4885
US-11384060-B2 Amide compounds and use thereof GLP1R, IAPP, GPR119 MMP2 2087/4885MMP3 3257/4885PPARG 93/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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