Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.53 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.53 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.41 |
| ▸ | LPL | P06858 | 2/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128383 | 0.90 | S1PR1 (0.50) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL15945997 | 0.89 | S1PR1 (0.51) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL2151091 | 0.83 | S1PR1 (0.47) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL28824373 | 0.81 | S1PR4 (0.39) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL2157970 | 0.80 | TDP1 (0.46) | S1PR1S1PR4S1PR5 | |
| SCHEMBL18631859 | 0.79 | HDAC4 (0.49) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL3130507 | 0.78 | HTR6 (0.47) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL15946031 | 0.78 | HDAC4 (0.48) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL26118267 | 0.77 | LPL (0.47) | S1PR1S1PR4S1PR5HDAC4MEF2D | |
| SCHEMBL15576268 | 0.76 | HDAC4 (0.56) | S1PR1S1PR4S1PR5HDAC4MEF2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160145198-A1 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. | 2016-05-26 | — | — | US | disclosed |
| US-9193669-B2 | Compounds for treating ophthalmic diseases and disorders | ACUCELA INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20140228443-A1 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145198-A1 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | PDE6D, CLN6, ALDH1A2 | S1PR1 367/4885S1PR4 517/4885S1PR5 573/4885 |
| US-20140228443-A1 | COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | PDE6D, CLN6, ALDH1A2 | S1PR1 367/4885S1PR4 517/4885S1PR5 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.