SCHEMBL15948153

SCHEMBL15948153

O=C(Cl)Cc1c(F)c(F)c(CC(=O)Cl)c(F)c1F

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
TAS1R3 Q7RTX0 1/20 0.32
TAS1R1 Q7RTX1 1/20 0.32
TAS1R2 Q8TE23 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6525902 0.97 TSHR (0.35) TSHRNPSR1TAS1R3TAS1R1TAS1R2
SCHEMBL15948244 0.95 TSHR (0.34) TSHRNPSR1TAS1R3TAS1R1TAS1R2
SCHEMBL15948283 0.92 CES2 (0.32) TSHRNPSR1TAS1R3TAS1R1TAS1R2
SCHEMBL2985954 0.76 CES2 (0.40)
SCHEMBL28819126 0.75 POLB (0.33)
SCHEMBL3259561 0.73 TAS1R3 (0.36) TSHRNPSR1TAS1R3TAS1R1TAS1R2
SCHEMBL15948192 0.73 AKR1B1 (0.42) TSHRTAS1R3TAS1R1TAS1R2
SCHEMBL3949072 0.72 MAPT (0.45)
SCHEMBL1884539 0.72 CES2 (0.40)
SCHEMBL11673206 0.71 GSK3B (0.38) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809451-B2 Fluorinated dicarboxylic acid derivative and polymer obtained therefrom CENTRAL GLASS COMPANY, LIMITED (JP) 2014-08-19 US disclosed
EP-2395040-A1 FLUORINATED DICARBOXYLIC ACID DERIVATIVE AND POLYMER OBTAINED THEREFROM Central Glass Company, Limited (JP) 2011-12-14 EP disclosed
US-20110301305-A1 Fluorinated Dicarboxylic Acid Derivative and Polymer Obtained Therefrom CENTRAL GLASS COMPANY, LIMITED (JP) 2011-12-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110301305-A1 Fluorinated Dicarboxylic Acid Derivative and Polymer Obtained Therefrom MCCC2, AFF2, F13A1 TSHR 4737/4885NPSR1 4475/4885TAS1R3 1028/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.