Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1885453 | 0.88 | MAPT (0.59) | MAPTTP53ALDH1A1KMT2AKDM4E | |
| SCHEMBL6864858 | 0.81 | CES2 (0.48) | MAPTTP53KMT2ACES2CES1 | |
| SCHEMBL2985954 | 0.80 | CES2 (0.40) | MAPTALDH1A1ALOX15KMT2ACES2 | |
| SCHEMBL503912 | 0.79 | AKR1B1 (0.56) | MAPTTP53ALDH1A1KMT2ACES2 | |
| SCHEMBL4717563 | 0.78 | TAAR1 (0.42) | MAPTTP53ALDH1A1ALOX15KMT2A | |
| SCHEMBL1884539 | 0.77 | CES2 (0.40) | MAPTTP53ALDH1A1ALOX15CES2 | |
| SCHEMBL3959168 | 0.77 | MAPT (0.45) | MAPTTP53KMT2ACES2CES1 | |
| SCHEMBL1461227 | 0.77 | CES2 (0.44) | MAPTTP53ALDH1A1KMT2ACES2 | |
| SCHEMBL6390159 | 0.77 | MAPK8 (0.49) | MAPTTP53KMT2ACES2CES1 | |
| Hydrochloric Acid SCHEMBL1372001 | 0.77 | AKR1B1 (0.54) | MAPTTP53ALDH1A1KMT2ACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B V (US) | 2022-04-07 | — | — | US | disclosed |
| US-11230555-B2 | Bicyclic RORγ modulators | ESCALIER BIOSCIENCES B.V. (US) | 2022-01-25 | — | — | US | disclosed |
| EP-3889160-A1 | THIAMINE COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | Shanghai Raising Pharmaceutical Co., Ltd. (CN) | 2021-10-06 | — | — | EP | disclosed |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. | 2021-02-25 | — | — | US | disclosed |
| EP-3765009-A1 | BICYCLIC ROR-GAMMA MODULATORS | Escalier Biosciences, BV (US) | 2021-01-20 | — | — | EP | disclosed |
| WO-2019177996-A1 | BICYCLIC ROR-GAMMA MODULATORS | ESCALIER BIOSCIENCES B.V. (US) | 2019-09-19 | — | — | WO | disclosed |
| WO-2009032754-A2 | HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-03-12 | — | — | WO | disclosed |
| US-20090062253-A1 | HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2009-03-05 | — | — | US | disclosed |
| US-20050239656-A1 | Pyridine compounds or salts thereof and herbicides containing the same | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2005-10-27 | — | — | US | disclosed |
| EP-1500650-A1 | PYRIDINE COMPOUNDS OR SALTS THEREOF AND HERBICIDES CONTAINING THE SAME | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2005-01-26 | — | — | EP | disclosed |
| US-5098922-A | Anticonvulsants | CIBA-GEIGY CORPORATION (US) | 1992-03-24 | — | — | US | disclosed |
| US-5045556-A | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |
| EP-0267147-B1 | ARALKYL-4H-1,2,4-TRIAZOLE DERIVATIVES | CIBA-GEIGY AG (CH) | 1991-08-07 | — | — | EP | disclosed |
| EP-0267147-A1 | Aralkyl-4H-1,2,4-triazole derivatives | CIBA-GEIGY AG (CH) | 1988-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239656-A1 | Pyridine compounds or salts thereof and herbicides containing the same | CBR3, CYP2C8, ABCC8 | MAPT 4272/4885TP53 1025/4885ALDH1A1 1490/4885 |
| US-11230555-B2 | Bicyclic RORγ modulators | RORC, RORA, RORB | MAPT 2269/4885TP53 3791/4885ALDH1A1 403/4885 |
| US-20090062253-A1 | HETEROCYCLODIAZEPINE CANNABINOID RECEPTOR MODULATORS FOR TREATMENT OF DISEASE | CNR2, CNR1, GPR18 | MAPT 4415/4885TP53 4797/4885ALDH1A1 4812/4885 |
| US-20210053987-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MAPT 2392/4885TP53 3459/4885ALDH1A1 287/4885 |
| US-20220106329-A1 | BICYCLIC ROR-GAMMA MODULATORS | RORA, RORC, RORB | MAPT 2392/4885TP53 3459/4885ALDH1A1 287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.