Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | FADS1 | O60427 | 1/20 | 0.41 |
| ▸ | CALML3 | P27482 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901414 | 0.76 | FADS1 (0.50) | FADS1GRM2DRD2 | |
| SCHEMBL2901413 | 0.76 | FADS1 (0.50) | FADS1GRM2DRD2 | |
| SCHEMBL2900121 | 0.74 | GRM2 (0.56) | FADS1CALML3GRM2 | |
| SCHEMBL15949339 | 0.73 | HSD11B1 (0.39) | HSD11B1CALML3FAAHNAAAHCRTR1 | |
| SCHEMBL2582267 | 0.71 | HSD11B1 (0.46) | HSD11B1FADS1GRM2 | |
| SCHEMBL6584299 | 0.70 | PDE4A (0.57) | GRM2 | |
| SCHEMBL2901527 | 0.70 | FADS1 (0.62) | FADS1GRM2 | |
| SCHEMBL2899140 | 0.70 | FADS1 (0.53) | FADS1FAAHGRM2 | |
| SCHEMBL2899139 | 0.70 | FADS1 (0.53) | FADS1FAAHGRM2 | |
| SCHEMBL2898927 | 0.70 | CNR2 (0.50) | FADS1HCRTR1HCRTR2GRM2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183228-B1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2014-08-20 | — | — | EP | disclosed |