Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | CALML3 | P27482 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949338 | 0.73 | HSD11B1 (0.44) | HSD11B1CALML3HCRTR1HCRTR2FAAH | |
| SCHEMBL13950146 | 0.66 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL957156 | 0.64 | HSD11B1 (0.79) | HSD11B1ALOX5 | |
| SCHEMBL249824 | 0.64 | PRKCI (0.70) | PRKCICFTRACMSD | |
| SCHEMBL30108284 | 0.64 | PRKCI (0.70) | PRKCICFTRACMSD | |
| SCHEMBL2900121 | 0.63 | GRM2 (0.56) | CALML3 | |
| SCHEMBL2901414 | 0.63 | FADS1 (0.50) | — | |
| SCHEMBL2901413 | 0.63 | FADS1 (0.50) | — | |
| SCHEMBL4191589 | 0.62 | PRKCI (0.72) | PRKCIACMSD | |
| SCHEMBL20794251 | 0.62 | DRD2 (0.40) | CALML3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183228-B1 | CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1 | VITAE PHARMACEUTICALS INC (US) | 2014-08-20 | — | — | EP | disclosed |