Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 3/20 | 0.45 |
| ▸ | ACACA | Q13085 | 3/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949225 | 0.89 | KDM4E (0.48) | KDM4EALDH1A1POLBL3MBTL1L3MBTL3 | |
| SCHEMBL15949432 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1POLBL3MBTL1L3MBTL3 | |
| SCHEMBL15949405 | 0.84 | ACACB (0.51) | KDM4EALDH1A1POLBL3MBTL1L3MBTL3 | |
| SCHEMBL15949302 | 0.84 | MEN1 (0.54) | KDM4EALDH1A1POLBMGLLHRH3 | |
| SCHEMBL15949180 | 0.84 | TACR2 (0.48) | KDM4EALDH1A1POLBACACBACACA | |
| SCHEMBL912358 | 0.81 | MGLL (0.53) | MGLLAPP | |
| SCHEMBL15949434 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1POLBL3MBTL1TSHR | |
| SCHEMBL15949250 | 0.80 | KMT2A (0.50) | KDM4EALDH1A1POLBL3MBTL1L3MBTL3 | |
| SCHEMBL15949415 | 0.80 | ALDH1A1 (0.48) | KDM4EALDH1A1POLBL3MBTL1L3MBTL3 | |
| SCHEMBL912264 | 0.79 | SMN1; SMN2 (0.48) | KDM4EALDH1A1POLBL3MBTL1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |