Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949302 | 0.89 | MEN1 (0.54) | ALDH1A1KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL15949250 | 0.89 | KMT2A (0.50) | ALDH1A1KDM4EPOLBL3MBTL1KMT2A | |
| SCHEMBL15949278 | 0.87 | MGLL (0.57) | ALDH1A1KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL911811 | 0.86 | MGLL (0.56) | ALDH1A1KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL15949180 | 0.84 | TACR2 (0.48) | ALDH1A1KDM4EPOLBKDM4AKDM5C | |
| SCHEMBL15949463 | 0.81 | OPRM1 (0.45) | ALDH1A1KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL15949434 | 0.81 | KDM4E (0.53) | ALDH1A1KDM4EPOLBL3MBTL1KMT2A | |
| SCHEMBL15949382 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EPOLBL3MBTL1KMT2A | |
| SCHEMBL910955 | 0.81 | POLB (0.48) | ALDH1A1KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL15949266 | 0.81 | POLB (0.56) | ALDH1A1KDM4EPOLBL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |