Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | MGLL | Q99685 | 8/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949352 | 0.90 | MGLL (0.57) | MGLLFAAH | |
| SCHEMBL912544 | 0.88 | HRH3 (0.67) | HRH3KCNH2MGLLFAAH | |
| SCHEMBL15949220 | 0.88 | HRH3 (0.59) | HRH3KCNH2MGLLFAAHSCN9A | |
| SCHEMBL913083 | 0.87 | MGLL (0.53) | HRH3KCNH2MGLLFAAHSCN9A | |
| SCHEMBL15949309 | 0.84 | MGLL (0.54) | HRH3KCNH2MGLLSCN9ASCN10A | |
| SCHEMBL913278 | 0.84 | MGLL (0.53) | HRH3KCNH2MGLLFAAHSCN9A | |
| SCHEMBL912124 | 0.82 | SLC6A7 (0.59) | MGLLFAAH | |
| SCHEMBL911859 | 0.81 | MGLL (0.58) | MGLLFAAH | |
| SCHEMBL694239 | 0.80 | MGLL (0.53) | MGLLFAAH | |
| SCHEMBL15949204 | 0.80 | MGLL (0.53) | MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |