Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 15/20 | 0.57 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949447 | 0.90 | HRH3 (0.53) | MGLLFAAH | |
| SCHEMBL913278 | 0.88 | MGLL (0.53) | MGLLFAAHCYP3A4GAAMAPT | |
| SCHEMBL699889 | 0.87 | MGLL (0.60) | MGLLFAAH | |
| SCHEMBL912124 | 0.87 | SLC6A7 (0.59) | MGLLFAAHSLC6A7ABL1BCR | |
| SCHEMBL693170 | 0.86 | MGLL (0.57) | MGLLCYP3A4GAAMAPTCYP2C9 | |
| SCHEMBL15949204 | 0.85 | MGLL (0.53) | MGLLFAAHRBP4SLC6A7ABL1 | |
| SCHEMBL694239 | 0.85 | MGLL (0.53) | MGLLFAAHRBP4SLC6A7ABL1 | |
| SCHEMBL912154 | 0.84 | MGLL (0.51) | MGLLFAAHCYP3A4GAAMAPT | |
| SCHEMBL912096 | 0.84 | L3MBTL1 (0.60) | MGLLFAAHGAAMAPTHTT | |
| SCHEMBL911859 | 0.84 | MGLL (0.58) | MGLLFAAHSLC6A7ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |