Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NAAA | Q02083 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911234 | 0.92 | ALDH1A1 (0.65) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL912523 | 0.92 | SLC6A7 (0.60) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL912218 | 0.92 | MGLL (0.56) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL912376 | 0.90 | MGLL (0.58) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL912093 | 0.90 | MGLL (0.58) | SLC6A7ALDH1A1MEN1KMT2APKM | |
| SCHEMBL14647865 | 0.90 | SLC6A7 (0.52) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL14648195 | 0.90 | MGLL (0.58) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL912086 | 0.89 | SLC6A7 (0.51) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL693102 | 0.87 | S1PR1 (0.53) | SLC6A7ALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL912442 | 0.87 | SLC6A7 (0.49) | SLC6A7ALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |