Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.45 |
| ▸ | ACACA | Q13085 | 2/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949495 | 0.86 | MGLL (0.51) | MGLLKDM4EALDH1A1POLBTP53 | |
| SCHEMBL15949401 | 0.86 | ACACB (0.50) | MGLLKDM4EALDH1A1POLBL3MBTL3 | |
| SCHEMBL693149 | 0.84 | L3MBTL3 (0.59) | MGLLKDM4EALDH1A1POLBL3MBTL3 | |
| SCHEMBL911856 | 0.83 | MGLL (0.48) | MGLLKDM4EALDH1A1POLBL3MBTL1 | |
| SCHEMBL694197 | 0.81 | MGLL (0.61) | MGLLKDM4EALDH1A1POLBTP53 | |
| SCHEMBL15949361 | 0.81 | L3MBTL3 (0.56) | MGLLKDM4EALDH1A1POLBL3MBTL3 | |
| SCHEMBL911366 | 0.79 | MGLL (0.48) | MGLLKDM4EALDH1A1POLBACACB | |
| SCHEMBL911458 | 0.79 | MGLL (0.54) | MGLLALDH1A1POLB | |
| SCHEMBL911200 | 0.79 | MGLL (0.51) | MGLLALDH1A1POLBACACBACACA | |
| SCHEMBL912400 | 0.78 | MGLL (0.53) | MGLLCYP3A4CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |