Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 6/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GPR6 | P46095 | 1/20 | 0.46 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 2/20 | 0.45 |
| ▸ | ACACA | Q13085 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693149 | 0.87 | L3MBTL3 (0.59) | MGLLALDH1A1KDM4EPOLBL3MBTL3 | |
| SCHEMBL15949484 | 0.86 | MGLL (0.48) | MGLLALDH1A1KDM4EPOLBL3MBTL3 | |
| SCHEMBL693894 | 0.86 | POLB (0.52) | MGLLALDH1A1KDM4EPOLBL3MBTL3 | |
| SCHEMBL694197 | 0.84 | MGLL (0.61) | MGLLALDH1A1KDM4EPOLBL3MBTL3 | |
| SCHEMBL15949361 | 0.83 | L3MBTL3 (0.56) | MGLLALDH1A1KDM4EPOLBL3MBTL3 | |
| SCHEMBL911468 | 0.79 | MGLL (0.47) | MGLLALDH1A1KDM4EPOLBL3MBTL1 | |
| SCHEMBL910982 | 0.79 | MGLL (0.52) | MGLL | |
| SCHEMBL15240920 | 0.79 | MGLL (0.51) | MGLLALDH1A1KDM4EPOLBL3MBTL3 | |
| SCHEMBL912035 | 0.79 | MGLL (0.54) | MGLLPOLBACACBACACA | |
| SCHEMBL15949266 | 0.78 | POLB (0.56) | MGLLALDH1A1KDM4EPOLBL3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |