Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 10/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949446 | 0.88 | MGLL (0.53) | MGLLL3MBTL1SLC6A7L3MBTL3 | |
| SCHEMBL912557 | 0.88 | MGLL (0.57) | MGLLL3MBTL1KDM4EALDH1A1L3MBTL3 | |
| SCHEMBL15949410 | 0.87 | SMN1; SMN2 (0.45) | MGLLL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL15949273 | 0.81 | CA12 (0.47) | L3MBTL1KDM4EALDH1A1L3MBTL3 | |
| SCHEMBL912573 | 0.80 | MGLL (0.54) | MGLLL3MBTL1KDM4EALDH1A1SLC6A7 | |
| SCHEMBL912279 | 0.79 | MGLL (0.55) | MGLLSLC6A7 | |
| SCHEMBL15949402 | 0.79 | RXRA (0.50) | MGLLALDH1A1SLC6A7 | |
| SCHEMBL15949408 | 0.79 | HSD11B1 (0.42) | MGLLL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL14647944 | 0.79 | MGLL (0.59) | MGLLKDM4EALDH1A1 | |
| SCHEMBL15949381 | 0.76 | HRH3 (0.54) | MGLLL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |