Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | MGLL | Q99685 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699558 | 0.86 | MGLL (0.49) | LMNASMN1; SMN2MGLLHPGD | |
| SCHEMBL911056 | 0.82 | ALDH1A1 (0.66) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15949311 | 0.82 | SMN1; SMN2 (0.52) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL912678 | 0.82 | NR4A2 (0.47) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL701276 | 0.82 | LMNA (0.51) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL911066 | 0.78 | SMN1; SMN2 (0.55) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14647886 | 0.77 | MGLL (0.47) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL912264 | 0.76 | SMN1; SMN2 (0.48) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL912680 | 0.76 | LMNA (0.49) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL15949207 | 0.76 | MGLL (0.54) | LMNAMEN1KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |