⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698748 | 0.75 | — | — | |
| SCHEMBL8056627 | 0.73 | — | — | |
| SCHEMBL28431586 | 0.72 | — | — | |
| SCHEMBL28706826 | 0.72 | — | — | |
| SCHEMBL1061431 | 0.72 | — | — | |
| SCHEMBL8600847 | 0.71 | — | — | |
| SCHEMBL22558041 | 0.70 | ALDH1A1 (0.32) | — | |
| SCHEMBL475925 | 0.70 | ALDH1A1 (0.33) | — | |
| SCHEMBL475924 | 0.69 | — | — | |
| SCHEMBL6274000 | 0.69 | LMNA (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2220085-B1 | FLUOROALKYL TETRABENAZINE CARBINOL COMPOUNDS AS IMAGING AGENTS AND PROBES | GEN ELECTRIC (US) | 2014-02-12 | — | — | EP | disclosed |
| US-8013161-B1 | Fluoroalkyl tetrabenazine carbinol compounds as imaging agents and probes | GENERAL ELECTRIC COMPANY (US) | 2011-09-06 | — | — | US | disclosed |
| US-20110206609-A1 | FLUOROALKYL TETRABENAZINE CARBINOL COMPOUNDS AS IMAGING AGENTS AND PROBES | GENERAL ELECTRIC COMPANY (US) | 2011-08-25 | — | — | US | disclosed |
| US-7919622-B2 | Intermediates for fluorinated tetrabenazine carbinol compounds imaging agents and probes | GENERAL ELECTRIC COMPANY | 2011-04-05 | — | — | US | disclosed |
| US-20090149654-A1 | INTERMEDIATES FOR FLUORINATED TETRABENAZINE CARBINOL COMPOUNDS IMAGING AGENTS AND PROBES | GENERAL ELECTRIC COMPANY (US) | 2009-06-11 | — | — | US | disclosed |