Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.56 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.56 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.50 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.50 |
| ▸ | KDM4A | O75164 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.50 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.50 |
| ▸ | TET3 | O43151 | 1/20 | 0.50 |
| ▸ | GABRP | O00591 | 2/20 | 0.48 |
| ▸ | GABRD | O14764 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL935212 | 1.00 | TP53 (0.69) | TP53LMNAEGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL4366411 | 0.97 | TP53 (0.65) | TP53LMNAEGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL8148316 | 0.97 | TP53 (0.65) | TP53LMNAEGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL8157901 | 0.97 | TP53 (0.65) | TP53LMNAEGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL8827899 | 0.94 | TP53 (0.61) | TP53LMNAEGLN1ALKBH5SUCNR1 | |
| Succinic Acid SCHEMBL15066279 | 0.92 | TP53 (0.58) | TP53LMNAEGLN1ALKBH5SUCNR1 | |
| Levulinic Acid SCHEMBL28010828 | 0.89 | LMNA (0.70) | TP53LMNAEGLN1ALKBH5SUCNR1 | |
| Glutarate SCHEMBL28852051 | 0.88 | SLC22A6 (0.61) | TP53LMNACYP1A2TET2KDM2A | |
| Adipic Acid SCHEMBL5306019 | 0.88 | LMNA (0.61) | TP53LMNAOR51E2SLC22A6 | |
| Succinic Acid SCHEMBL9714183 | 0.87 | TP53 (0.52) | TP53LMNAEGLN1ALKBH5SUCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2767554-B9 | FAST DEGRADABLE POLYESTER POLYMER AND PREPARATION METHOD AND USE THEREOF | HUANG BIN (US) | 2018-03-07 | — | — | EP | disclosed |
| EP-2767554-B1 | FAST DEGRADABLE POLYESTER POLYMER AND PREPARATION METHOD AND USE THEREOF | HUANG BIN (US) | 2017-10-04 | — | — | EP | disclosed |
| EP-2767554-A1 | FAST DEGRADABLE POLYESTER POLYMER AND PREPARATION METHOD AND USE THEREOF | Huang, Bin (US) | 2014-08-20 | — | — | EP | disclosed |