Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16202271 | 0.94 | LMNA (0.46) | ALDH1A1NPC1MAPTRAB9ARECQL | |
| SCHEMBL8495637 | 0.90 | POLB (0.45) | ALDH1A1NPC1MAPTRAB9ARECQL | |
| SCHEMBL1497771 | 0.87 | FFAR1 (0.53) | ALDH1A1NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9891052 | 0.85 | S1PR1 (0.42) | ALDH1A1NPC1RAB9ATAAR1KDM4E | |
| SCHEMBL17427772 | 0.85 | PLK1 (0.44) | ALDH1A1THRBPOLBKDM4E | |
| SCHEMBL24430171 | 0.85 | NPC1 (0.45) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5992356 | 0.84 | DPP4 (0.54) | NPC1MAPTRAB9ATHRBHDAC2 | |
| SCHEMBL8496037 | 0.84 | S1PR1 (0.52) | ALDH1A1NPC1MAPTRAB9ATAAR1 | |
| SCHEMBL588956 | 0.84 | POLB (0.42) | NPC1MAPTTAAR1SMN1; SMN2POLB | |
| SCHEMBL7614431 | 0.83 | ALDH1A1 (0.40) | ALDH1A1NPC1MAPTRAB9ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111087357-B | Preparation method of Prisamod | 中国医学科学院药物研究所 | 2022-07-19 | — | — | CN | disclosed |
| CN-111087356-B | Preparation method of Iguratimod | 中国医学科学院药物研究所 | 2022-06-21 | — | — | CN | disclosed |
| US-20220153684-A1 | PROCESS FOR PREPARATION OF FINGOLIMOD HYDROCHLORIDE | SHIVALIK RASAYAN LIMITED (IN) | 2022-05-19 | — | — | US | disclosed |
| CN-111087356-A | Preparation method of Iguratimod | 中国医学科学院药物研究所 | 2020-05-01 | — | — | CN | disclosed |
| CN-111087357-A | Preparation method of Prisamod | 中国医学科学院药物研究所 | 2020-05-01 | — | — | CN | disclosed |
| US-9133096-B2 | Process for the production of 2-amino-2[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein | NOVARTIS AG (CH) | 2015-09-15 | — | — | US | disclosed |
| EP-2268603-B1 | PROCESS FOR THE PREPARATION OF 2-AMINO-2- [2- (4-C3-C21-ALKYL-PHENYL)ETHYL]PROPANE-1, 3-DIOLS | NOVARTIS AG (CH) | 2015-04-22 | — | — | EP | disclosed |
| US-8809571-B2 | Process for the production of 2-amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein | NOVARTIS AG (CH) | 2014-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153684-A1 | PROCESS FOR PREPARATION OF FINGOLIMOD HYDROCHLORIDE | S1PR2, S1PR4, S1PR5 | ALDH1A1 1249/4885NPC1 1348/4885MAPT 2344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.