Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1175576 | 0.82 | TDP1 (0.58) | TSHRTDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL4466131 | 0.82 | TSHR (0.49) | TSHRTDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL8528733 | 0.81 | TSHR (0.47) | TSHRTDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL23311962 | 0.78 | CA1 (0.57) | TSHRTDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL15958967 | 0.78 | CA12 (0.54) | ALDH1A1POLBSMN1; SMN2ESR1HSD17B10 | |
| SCHEMBL24125027 | 0.77 | CDC25B (0.50) | TSHRTDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL14724886 | 0.77 | TSHR (0.44) | TSHRTDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL19936703 | 0.77 | HCAR3 (0.51) | TSHRTDP1ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL12132608 | 0.75 | TSHR (0.46) | TSHRTDP1ALDH1A1POLBL3MBTL1 | |
| SCHEMBL310259 | 0.74 | CES2 (0.63) | TSHRTDP1ALDH1A1POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |