Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.62 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.58 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | MUSK | O15146 | 1/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1596071 | 1.00 | KDR (0.62) | KDRCHEK1MAP2K4MAPK6MAPK1 | |
| SCHEMBL11924704 | 0.90 | KDR (0.59) | KDRCHEK1MAP2K4MAPK6MAPK1 | |
| SCHEMBL1597265 | 0.85 | KDR (0.65) | KDRCHEK1MAP2K4MAPK6FGFR1 | |
| SCHEMBL1597267 | 0.85 | KDR (0.65) | KDRCHEK1MAP2K4MAPK6FGFR1 | |
| SCHEMBL5922406 | 0.81 | CHEK1 (0.48) | KDRCHEK1FGFR1AURKATTR | |
| SCHEMBL5922402 | 0.81 | CHEK1 (0.48) | KDRCHEK1FGFR1AURKATTR | |
| SCHEMBL2458766 | 0.81 | CHEK1 (0.67) | KDRCHEK1MAP2K4MAPK6FGFR1 | |
| SCHEMBL2458765 | 0.81 | CHEK1 (0.67) | KDRCHEK1MAP2K4MAPK6FGFR1 | |
| SCHEMBL6224476 | 0.80 | CHEK1 (0.53) | KDRCHEK1MAP2K4MAPK6MAPK1 | |
| SCHEMBL6224474 | 0.80 | CHEK1 (0.53) | KDRCHEK1MAP2K4MAPK6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919517-B2 | Indazole derivatives | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-04-05 | — | — | US | disclosed |
| US-20090082348-A1 | INDAZOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-03-26 | — | — | US | disclosed |
| US-7470717-B2 | Indazole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2008-12-30 | — | — | US | disclosed |
| US-20070117856-A1 | Indazole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-24 | — | — | US | disclosed |
| EP-1652842-A1 | INDAZOLE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117856-A1 | Indazole derivatives | IGF1R, NR0B2, ADRA2B | KDR 383/4885CHEK1 2191/4885MAP2K4 2138/4885 |
| US-20090082348-A1 | INDAZOLE DERIVATIVES | IGF1R, NR0B2, ADRA2B | KDR 383/4885CHEK1 2191/4885MAP2K4 2138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.