Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 7/20 | 0.47 |
| ▸ | DHPS | P49366 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15956951 | 0.87 | LIPE (0.42) | LIPERAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL16343945 | 0.86 | LIPE (0.47) | LIPEDHPSNR1H4RAB9ANPC1 | |
| SCHEMBL15979558 | 0.83 | LIPE (0.47) | LIPEDHPSNR1H4RAB9ANPC1 | |
| SCHEMBL104612 | 0.81 | RAB9A (0.54) | LIPEDHPSNR1H4RAB9ANPC1 | |
| SCHEMBL29709477 | 0.81 | RAB9A (0.54) | LIPEDHPSNR1H4RAB9ANPC1 | |
| SCHEMBL15964586 | 0.80 | LIPE (0.50) | LIPEDHPSNR1H4RAB9ANPC1 | |
| SCHEMBL15956089 | 0.79 | RAB9A (0.49) | DHPSNR1H4RAB9ANPC1ALDH1A1 | |
| SCHEMBL3720444 | 0.76 | LIPE (0.46) | LIPERAB9ANPC1ALDH1A1MAPT | |
| SCHEMBL15956659 | 0.76 | LIPE (0.43) | LIPEDHPSMAPTCA1CA2 | |
| SCHEMBL3705786 | 0.75 | LIPE (0.42) | LIPEHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014125408-A2 | SUBSTITUTED 1H-PYRROLOPYRIDINONE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-08-21 | — | — | WO | disclosed |