SCHEMBL1596478

SCHEMBL1596478

COC(=O)[C@H](C)Nc1ccc([N+](=O)[O-])cc1[N+](=O)[O-]

nearest known ligand 0.72

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CRHBP P24387 1/20 0.58
CRHR2 Q13324 1/20 0.58
MAPT P10636 8/20 0.53
MAPK1 P28482 6/20 0.53
TDP1 Q9NUW8 5/20 0.53
SMN1; SMN2 Q16637 4/20 0.53
ALDH1A1 P00352 5/20 0.52
L3MBTL1 Q9Y468 4/20 0.51
HTT P42858 1/20 0.51
KMT2A Q03164 2/20 0.51
HCAR3 P49019 3/20 0.50
KDM4E B2RXH2 1/20 0.50
LMNA P02545 3/20 0.49
GAA P10253 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8742125 1.00 CRHBP (0.58) CRHBPCRHR2MAPTMAPK1TDP1
SCHEMBL5945876 1.00 CRHBP (0.58) CRHBPCRHR2MAPTMAPK1TDP1
SCHEMBL6132129 0.86 ALDH1A1 (0.69) CRHBPCRHR2MAPTMAPK1TDP1
SCHEMBL26496466 0.86 ALDH1A1 (0.69) CRHBPCRHR2MAPTMAPK1TDP1
SCHEMBL8962619 0.86 ALDH1A1 (0.69) CRHBPCRHR2MAPTMAPK1TDP1
SCHEMBL9348638 0.86 ALDH1A1 (0.69) CRHBPCRHR2MAPTMAPK1TDP1
SCHEMBL10505373 0.86 ALDH1A1 (0.69) CRHBPCRHR2MAPTMAPK1TDP1
SCHEMBL14734344 0.85 MAPT (0.56) MAPTMAPK1SMN1; SMN2ALDH1A1KMT2A
SCHEMBL31424672 0.84 KMT2A (0.71) CRHBPCRHR2MAPTALDH1A1KMT2A
SCHEMBL3584166 0.83 CRHBP (0.51) CRHBPCRHR2MAPTMAPK1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8050531-B2 Dendrimer based terahertz generator APPLIED RESEARCH AND PHOTONICS, INC. 2011-11-01 US claimed
US-7919755-B2 Dendrimer based electro-optic sensor APPLIED RESEARCH AND PHOTONICS, INC. 2011-04-05 US claimed
US-7854505-B2 Passive and active photonic crystal structures and devices THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2010-12-21 US claimed
US-20090323014-A1 PASSIVE AND ACTIVE PHOTONIC CRYSTAL STRUCTURES AND DEVICES THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2009-12-31 US claimed
US-20080128618-A1 Dendrimer Based Electro-Optic Sensor APPLIED RESEARCH AND PHOTONICS, INC. 2008-06-05 US claimed
US-20080099698-A1 Dendrimer Based Terahertz Generator APPLIED RESEARCH AND PHOTONICS, INC. 2008-05-01 US claimed
US-6306203-B1 FOR USE IN INK JET PRINTING, INCLUDING PIEZOELECTRIC INK JET PRINTING AND ACOUSTIC INK JET PRINTING XEROX CORPORATION 2001-10-23 US claimed
EP-0186999-B1 OPTICAL COMPOSITIONS BRITISH TELECOMMUNICATIONS public limited company (GB) 1989-03-15 EP claimed
US-4746577-A VINYLIDENE FLUORIDE COPOLYMER AND OPTOELECTRONIC ADDITIVE BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY (GB) 1988-05-24 US claimed
EP-0186999-A1 Optical compositions BRITISH TELECOMMUNICATIONS public limited company (GB) 1986-07-09 EP claimed
US-9093810-B2 Dendrimer based terahertz generator APPLIED RESEARCH AND PHOTONICS, INC. (US) 2015-07-28 US disclosed
US-20120099827-A1 DENDRIMER BASED TERAHERTZ GENERATOR APPLIED RESEARCH AND PHOTONICS, INC. 2012-04-26 US disclosed
US-8050531-B2 Dendrimer based terahertz generator APPLIED RESEARCH AND PHOTONICS, INC. 2011-11-01 US disclosed
US-7919755-B2 Dendrimer based electro-optic sensor APPLIED RESEARCH AND PHOTONICS, INC. 2011-04-05 US disclosed
US-7854505-B2 Passive and active photonic crystal structures and devices THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2010-12-21 US disclosed
US-4746577-A VINYLIDENE FLUORIDE COPOLYMER AND OPTOELECTRONIC ADDITIVE BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY (GB) 1988-05-24 US disclosed
US-4746577-A VINYLIDENE FLUORIDE COPOLYMER AND OPTOELECTRONIC ADDITIVE BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY (GB) 1988-05-24 US disclosed
EP-0258719-A2 Two-layer system CIBA-GEIGY AG (CH) 1988-03-09 EP disclosed
EP-0186999-A1 Optical compositions BRITISH TELECOMMUNICATIONS public limited company (GB) 1986-07-09 EP disclosed
EP-0186999-A1 Optical compositions BRITISH TELECOMMUNICATIONS public limited company (GB) 1986-07-09 EP disclosed