Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5945876 | 0.85 | CRHBP (0.58) | MAPTMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL1596478 | 0.85 | CRHBP (0.58) | MAPTMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8742125 | 0.85 | CRHBP (0.58) | MAPTMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL3322365 | 0.85 | MAPT (0.56) | MAPTRAB9AMAPK1SMN1; SMN2NPC1 | |
| SCHEMBL7362765 | 0.84 | HCAR3 (0.58) | MAPTRAB9AMAPK1SMN1; SMN2NPC1 | |
| SCHEMBL31424672 | 0.83 | KMT2A (0.71) | MAPTRAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL31607362 | 0.82 | KMT2A (0.51) | MAPTMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL31607343 | 0.82 | KMT2A (0.51) | MAPTMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL24202566 | 0.80 | ALDH1A1 (0.57) | MAPTRAB9AMAPK1SMN1; SMN2NPC1 | |
| SCHEMBL24202568 | 0.80 | ALDH1A1 (0.57) | MAPTRAB9AMAPK1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013034755-A1 | TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | H. LUNDBECK A/S (DK) | 2013-03-14 | — | — | WO | disclosed |
| WO-2013027794-A1 | NOVEL COMPOUND AND USE THEREOF AS PDE10 INHIBITOR | 田辺三菱製薬株式会社 (JP) | 2013-02-28 | — | — | WO | disclosed |