Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.46 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.46 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28978045 | 0.88 | HTT (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL9216971 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL6823133 | 0.87 | SMN1; SMN2 (0.67) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL7282881 | 0.87 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL6825290 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL6948530 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL15140566 | 0.86 | SMN1; SMN2 (0.72) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL8553423 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL6948532 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH | |
| SCHEMBL5763722 | 0.84 | BCHE (0.63) | SMN1; SMN2NPC1RAB9ACYP2C19FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956450-B1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | UNIV MUENCHEN TECH (DE) | 2018-07-25 | — | — | EP | disclosed |
| US-9637471-B2 | Hydroxyindalpine derivatives and their medical use | TECHNISCHE UNIVERSITAT MUNCHEN (DE) | 2017-05-02 | — | — | US | disclosed |
| US-9637471-B2 | Hydroxyindalpine derivatives and their medical use | TECHNISCHE UNIVERSITAT MUNCHEN (DE) | 2017-05-02 | — | — | US | disclosed |
| US-20150376164-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | TECHNISCHE UNIVERSITAT MUNCHEN (DE) | 2015-12-31 | — | — | US | disclosed |
| US-20150376164-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | TECHNISCHE UNIVERSITAT MUNCHEN (DE) | 2015-12-31 | — | — | US | disclosed |
| WO-2014125084-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | Technische Universität München (DE) | 2014-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376164-A1 | HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE | HTR5A, HTR4, HTR6 | SMN1; SMN2 3273/4885NPC1 772/4885RAB9A 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.