Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30198157 | 0.84 | GRM2 (0.40) | ALDH1A1USP2HPGDTSHRMAPK1 | |
| SCHEMBL24054967 | 0.84 | GRM2 (0.40) | ALDH1A1USP2HPGDTSHRMAPK1 | |
| SCHEMBL24074349 | 0.83 | ELANE (0.41) | ALDH1A1USP2HPGDTSHRMAPK1 | |
| SCHEMBL6732982 | 0.81 | ALDH1A1 (0.40) | ALDH1A1TSHRMAPK1GRM2NPSR1 | |
| SCHEMBL15966707 | 0.81 | ALDH1A1 (0.42) | ALDH1A1USP2HPGDTSHRMAPK1 | |
| SCHEMBL28357403 | 0.79 | ELANE (0.44) | USP2HPGDTSHRMAPK1MEN1 | |
| SCHEMBL15966770 | 0.79 | JAK2 (0.46) | ALDH1A1USP2HPGDGRM2MEN1 | |
| SCHEMBL24073980 | 0.78 | MEN1 (0.48) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL30339031 | 0.78 | MEN1 (0.48) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL6305077 | 0.73 | ALDH1A1 (0.59) | ALDH1A1USP2HPGDTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757369-B2 | Heterocyclic GSK-3 allosteric modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2017-09-12 | — | — | US | disclosed |
| US-20170196850-A1 | Heterocyclic GSK-3 Allosteric Modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2017-07-13 | — | — | US | disclosed |
| EP-2769720-B1 | HETEROCYCLIC GSK-3 ALLOSTERIC MODULATORS | CONSEJO SUPERIOR DE INVESTIG CIENTÍFICAS (CSIC) (ES) | 2017-03-29 | — | — | EP | disclosed |
| US-9585879-B2 | Heterocyclic GSK-3 allosteric modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2017-03-07 | — | — | US | disclosed |
| US-20160113918-A1 | Heterocyclic GSK-3 Allosteric Modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2016-04-28 | — | — | US | disclosed |
| US-9193688-B2 | Heterocyclic GSK-3 allosteric modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2015-11-24 | — | — | US | disclosed |
| US-20150057311-A1 | Heterocyclic GSK-3 Allosteric Modulators | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC) (ES) | 2015-02-26 | — | — | US | disclosed |
| EP-2769720-A1 | HETEROCYCLIC GSK-3 ALLOSTERIC MODULATORS | Consejo Superior De Investigaciones Científicas (CSIC) (ES) | 2014-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170196850-A1 | Heterocyclic GSK-3 Allosteric Modulators | GSK3B, GSK3A, GSKIP | ALDH1A1 3820/4885USP2 2756/4885HPGD 2265/4885 |
| US-20160113918-A1 | Heterocyclic GSK-3 Allosteric Modulators | GSK3B, GSK3A, GSKIP | ALDH1A1 3820/4885USP2 2756/4885HPGD 2265/4885 |
| US-20150057311-A1 | Heterocyclic GSK-3 Allosteric Modulators | GSK3B, GSK3A, GSKIP | ALDH1A1 3820/4885USP2 2756/4885HPGD 2265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.