Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15967222 | 0.99 | CCR2 (0.52) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL15966994 | 0.98 | CCR2 (0.53) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL15967108 | 0.96 | CCR2 (0.54) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL5513284 | 0.87 | GPR139 (0.52) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL5509346 | 0.87 | CCR2 (0.47) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL4275117 | 0.86 | CCR2 (0.56) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL5513116 | 0.85 | CACNA1H (0.46) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL15967036 | 0.85 | CCR2 (0.46) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL3763868 | 0.85 | SLC6A9 (0.51) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 | |
| SCHEMBL5506757 | 0.84 | NAMPT (0.46) | CCR2TAS1R3TAS1R1TAS1R2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | claimed |
| EP-1869019-B1 | BICYCLIC [3.1.0] HETEROARYL AMIDES AS TYPE I GLYCINE TRANSPORT INHIBITORS | PFIZER PROD INC (US) | 2014-08-27 | — | — | EP | disclosed |