Sugi Predict

Sugi Predict / Compounds / SCHEMBL1597059

SCHEMBL1597059

SCHEMBL1597059

NC[C@@H]1CCCN1C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.48
▸ L3MBTL1 Q9Y468 1/20 0.48
▸ DPP4 P27487 4/20 0.42
▸ FAP Q12884 3/20 0.42
▸ PREP P48147 2/20 0.42
▸ DPP8 Q6V1X1 2/20 0.42
▸ DPP9 Q86TI2 2/20 0.42
▸ ACE P12821 7/20 0.38
▸ REN P00797 3/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ F2 P00734 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ LTA4H P09960 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ PEPD P12955 1/20 0.38
▸ ALOX15 P16050 1/20 0.38
▸ PTGS1 P23219 1/20 0.38
▸ HTR2A P28223 1/20 0.38
▸ PTGS2 P35354 1/20 0.38
▸ HRH1 P35367 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1597060 1.00 POLB (0.48) POLBL3MBTL1DPP4FAPPREP
SCHEMBL3335647 1.00 POLB (0.48) POLBL3MBTL1DPP4FAPPREP
Hydrochloric Acid SCHEMBL11895384 0.98 POLB (0.47) POLBL3MBTL1DPP4FAPPREP
Hydrochloric Acid SCHEMBL11896218 0.98 POLB (0.47) POLBL3MBTL1DPP4FAPPREP
SCHEMBL1596883 0.94 POLB (0.42) POLBL3MBTL1DPP4FAPPREP
SCHEMBL1596887 0.94 POLB (0.42) POLBL3MBTL1DPP4FAPPREP
SCHEMBL2679802 0.94 POLB (0.42) POLBL3MBTL1DPP4FAPPREP
Hydrochloric Acid SCHEMBL20570928 0.92 POLB (0.41) POLBL3MBTL1DPP4FAPPREP
Tert-Butanol SCHEMBL28547075 0.91 POLB (0.42) POLBL3MBTL1DPP4FAPPREP
SCHEMBL29043519 0.89 POLB (0.41) POLBL3MBTL1DPP4FAPPREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113412259-B Difunctional compounds for degrading BTK via the ubiquitin proteasome pathway 紐力克斯治疗公司 2024-07-16 — — CN disclosed
CN-118355020-A Therapeutic compounds for HIV virus infection 吉利德科学公司 2024-07-16 — — CN disclosed
US-20240199655-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2024-06-20 — — US disclosed
CN-117986158-A Substituted biphenyl compound, preparation method and application 云南大学 2024-05-07 — — CN disclosed
US-20240059677-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR CEREVANCE LTD (GB) 2024-02-22 — — US disclosed
US-11827656-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2023-11-28 — — US disclosed
CN-116969920-A Fused pyridazine derivative, preparation method and medical application thereof 上海辉启生物医药科技有限公司 2023-10-31 — — CN disclosed
EP-4211118-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR Cerevance, Inc. (US) 2023-07-19 — — EP disclosed
CN-116348451-A ENPP1 modulators and uses thereof 维艾尔生物科技有限公司 2023-06-27 — — CN disclosed
WO-2023086432-A1 PRODRUGS OF NEUROSTEROID ANALOGS AND USES THEREOF EMORY UNIVERSITY (US) 2023-05-19 — — WO disclosed
CN-1832947-A Thiazole derivatives as npy antagonists HOFFMANN LA ROCHE (CH) 2006-09-13 — — CN disclosed
US-20050234101-A1 Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-10-20 — — US disclosed
US-20040143115-A1 N-aroyl cyclic amines SMITHKLINE BEECHAM LIMITED (GB) 2004-07-22 — — US disclosed
WO-2004041807-A1 NOVEL COMPOUNDS GLAXO GROUP LIMITED (GB) 2004-05-21 — — WO disclosed
EP-1385845-A1 N-AROYL CYCLIC AMINES SMITHKLINE BEECHAM PLC (GB) 2004-02-04 — — EP disclosed
EP-0997474-B1 Antithrombotic agents PFIZER (US) 2003-10-29 — — EP disclosed
WO-2002090355-A1 N-AROYL CYCLIC AMINES SMITHKLINE BEECHAM P.L.C. (GB) 2002-11-14 — — WO disclosed
US-6417203-B1 HETEROCYCLIC AMIDES PFIZER INC. 2002-07-09 — — US disclosed
US-6180627-B1 INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES PFIZER INC. 2001-01-30 — — US disclosed
EP-0997474-A1 Antithrombotic agents PFIZER INC. (US) 2000-05-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827656-B2 Immunoproteasome inhibitors PSMC2, PSMB7, PSMB2 POLB 692/4885L3MBTL1 3263/4885DPP4 1301/4885
US-20240199655-A1 Immunoproteasome Inhibitors PSMC2, PSMB7, PSMB2 POLB 692/4885L3MBTL1 3263/4885DPP4 1301/4885
US-20240059677-A1 SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR CHRNA6, CHRM2, CHRNA1 POLB 1342/4885L3MBTL1 1269/4885DPP4 803/4885
US-20040143115-A1 N-aroyl cyclic amines HCRTR1, HCRTR2, CNR1 POLB 3607/4885L3MBTL1 3402/4885DPP4 3918/4885
US-20050234101-A1 Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds MCHR1, GPR119, MCHR2 POLB 4765/4885L3MBTL1 1955/4885DPP4 276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.