SCHEMBL15972175

SCHEMBL15972175

COC(=O)c1cc(OC)c(Br)cc1[N+](=O)[O-]

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.51
MAPT P10636 2/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
HTT P42858 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.47
NPC1 O15118 1/20 0.47
CYP3A4 P08684 1/20 0.47
LMNA P02545 2/20 0.46
KDM4E B2RXH2 1/20 0.45
PKM P14618 2/20 0.45
TDP1 Q9NUW8 1/20 0.44
SIRT6 Q8N6T7 1/20 0.44
PDGFRB P09619 1/20 0.44
FGFR1 P11362 1/20 0.44
PDGFRA P16234 1/20 0.44
FLT1 P17948 1/20 0.44
FGFR3 P22607 1/20 0.44
KDR P35968 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31152002 0.92 POLB (0.44) POLBMAPTMEN1KMT2AHTT
SCHEMBL1953578 0.87 POLB (0.61) POLBMAPTMEN1KMT2AHTT
SCHEMBL31697373 0.87 MAPT (0.43) POLBMAPTMEN1KMT2AHTT
SCHEMBL16636780 0.86 LCK (0.56) POLBMAPTMEN1KMT2AHTT
SCHEMBL22324330 0.86 LCK (0.56) POLBMAPTMEN1KMT2AHTT
SCHEMBL2899450 0.86 POLB (0.52) POLBMAPTMEN1KMT2AHTT
SCHEMBL22324347 0.85 POLB (0.53) POLBMAPTMEN1KMT2AHTT
SCHEMBL19426395 0.85 POLB (0.56) POLBMAPTMEN1KMT2AHTT
SCHEMBL24616176 0.85 POLB (0.41) POLBMAPTMEN1KMT2AHTT
SCHEMBL27191744 0.84 PDE5A (0.42) POLBMAPTMEN1KMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4192454-B1 AZABICYCLO-AMINO-TRIAZINE COMPOUNDS FOR MODULATING SPLICING FOR THE TREATMENT OF NEUROLOGICAL DISEASES SKYHAWK THERAPEUTICS INC (US) 2026-04-22 EP disclosed
US-12509460-B2 Methods and compositions for modulating splicing SKYHAWK THERAPEUTICS, INC. (US) 2025-12-30 US disclosed
WO-2025109474-A1 SUBSTITUTED IMIDAZOARENES AND METHODS OF THEIR USE NOVARTIS AG (CH) 2025-05-30 WO disclosed
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2025-02-25 US disclosed
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-10-24 US disclosed
US-20240043441-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2024-02-08 US disclosed
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C ARAXES PHARMA LLC (US) 2024-01-23 US disclosed
US-20240009189-A1 1,4-DISUBSTITUTED PYRIDAZINE QUINOLNE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2024-01-11 US disclosed
US-20230331718-A1 COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-10-19 US disclosed
US-20230331718-A1 COMPOSITIONS FOR MODULATING SPLICING SKYHAWK THERAPEUTICS, INC. 2023-10-19 US disclosed
EP-3055290-A1 INHIBITORS OF KRAS G12C Araxes Pharma LLC (US) 2016-08-17 EP disclosed
US-20160184305-A1 1,4-DISUBSTITUTED PYRIDAZINE QUINOLNE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2016-06-30 US disclosed
EP-3027600-A1 1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS Novartis AG (CH) 2016-06-08 EP disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
US-20150239900-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC 2015-08-27 US disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015054572-A1 INHIBITORS OF KRAS G12C ARAXES PHARMA LLC (US) 2015-04-16 WO disclosed
WO-2015017589-A1 1,4-DISUBSTITUTED PYRIDAZINE DERIVATIVES AND THEIR USE FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS NOVARTIS AG (CH) 2015-02-05 WO disclosed
WO-2014128655-A1 SUBSTITUTED IMIDAZO[4,5-C]QUINOLINE DERIVATIVES AS BROMODOMAIN INHIBITORS AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) 2014-08-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230331718-A1 COMPOSITIONS FOR MODULATING SPLICING RBM17, SF3B1, SNRPE POLB 1190/4885MAPT 2223/4885MEN1 3320/4885
US-12234244-B2 Substituted piperazines as inhibitors of KRAS G12C KRAS, NRAS, HRAS POLB 672/4885MAPT 229/4885MEN1 1052/4885
US-12509460-B2 Methods and compositions for modulating splicing SF3B1, RTCB, RBM17 POLB 562/4885MAPT 4636/4885MEN1 4196/4885
US-20240009189-A1 1,4-DISUBSTITUTED PYRIDAZINE QUINOLNE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, CLN6, PMP22 POLB 735/4885MAPT 991/4885MEN1 787/4885
US-11878985-B2 Substituted quinazolines as inhibitors of KRAS G12C KRAS, NRAS, HRAS POLB 603/4885MAPT 761/4885MEN1 188/4885
US-20160184305-A1 1,4-DISUBSTITUTED PYRIDAZINE QUINOLNE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS SMN1; SMN2, SCN5A, SF3B5 POLB 898/4885MAPT 1231/4885MEN1 957/4885
US-20240352028-A1 SUBSTITUTED QUINAZOLINES AS INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS POLB 603/4885MAPT 761/4885MEN1 188/4885
US-20150239900-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS POLB 639/4885MAPT 279/4885MEN1 138/4885
US-20240043441-A1 INHIBITORS OF KRAS G12C KRAS, NRAS, HRAS POLB 639/4885MAPT 279/4885MEN1 138/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.