Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15989350 | 1.00 | MAOA (0.32) | MAOAMAOBPYCR1 | |
| SCHEMBL15973528 | 0.81 | MAOA (0.37) | MAOAMAOB | |
| SCHEMBL15973530 | 0.81 | MAOA (0.37) | MAOAMAOB | |
| SCHEMBL15241093 | 0.79 | HPGD (0.48) | PYCR1 | |
| SCHEMBL15241092 | 0.79 | HPGD (0.48) | PYCR1 | |
| SCHEMBL15974363 | 0.78 | PYCR1 (0.32) | PYCR1 | |
| SCHEMBL15989349 | 0.78 | PYCR1 (0.32) | PYCR1 | |
| SCHEMBL15973145 | 0.76 | ERN1 (0.38) | MAOAMAOBPYCR1 | |
| SCHEMBL16844646 | 0.70 | PYCR1 (0.34) | PYCR1 | |
| SCHEMBL15619882 | 0.68 | PTGDR2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708337-B2 | Aryl amide-based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |
| EP-2958924-B1 | 5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) | BRISTOL MYERS SQUIBB CO (US) | 2016-12-28 | — | — | EP | disclosed |
| US-20160016967-A1 | ARYL AMIDE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2016-01-21 | — | — | US | disclosed |
| EP-2958924-A1 | 5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) | Bristol-Myers Squibb Company (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130258-A1 | 5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016967-A1 | ARYL AMIDE-BASED KINASE INHIBITORS | AAK1, ADCK1, NCK1 | MAOA 3584/4885MAOB 3728/4885PYCR1 3133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.