Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15975093 | 0.83 | PDE10A (0.42) | PDE10AALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL15975194 | 0.83 | PDE10A (0.40) | PDE10AALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11978656 | 0.82 | PDE10A (0.44) | MTNR1AMTNR1BPDE10AALDH1A1KDM4E | |
| SCHEMBL15975094 | 0.80 | CYP19A1 (0.47) | PDE10AALDH1A1CASP1HSD17B10USP2 | |
| SCHEMBL15975112 | 0.79 | MTNR1A (0.40) | MTNR1AMTNR1BPDE10AALDH1A1KDM4E | |
| SCHEMBL11978281 | 0.79 | TUBB4A (0.42) | PDE10AAGTR1ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4568577 | 0.79 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1KDM4EHPGD | |
| SCHEMBL4568450 | 0.78 | MTNR1A (0.50) | MTNR1AMTNR1BALDH1A1KDM4EGAA | |
| SCHEMBL4568574 | 0.78 | MTNR1A (0.47) | MTNR1AMTNR1BALDH1A1KDM4EHPGD | |
| SCHEMBL4568448 | 0.77 | MTNR1A (0.48) | MTNR1AMTNR1BALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |