Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15975203 | 0.95 | PDE10A (0.38) | MTNR1AMTNR1BPDE10ACYP3A4CYP2D6 | |
| SCHEMBL11979702 | 0.83 | PDE10A (0.39) | PDE10ACYP3A4CYP2D6CYP1A2CYP2E1 | |
| SCHEMBL11978295 | 0.82 | PDE10A (0.37) | PDE10ACYP3A4CYP2D6CYP1A2CYP2E1 | |
| SCHEMBL15975201 | 0.82 | PDE10A (0.38) | MTNR1AMTNR1BPDE10ACYP3A4CYP2D6 | |
| SCHEMBL11979697 | 0.81 | TUBB4A (0.43) | MTNR1AMTNR1BPDE10ACYP3A4CYP2D6 | |
| SCHEMBL15975133 | 0.80 | PDE10A (0.37) | PDE10AMAPTKDM4EALDH1A1DYRK1A | |
| SCHEMBL15975129 | 0.79 | MTNR1A (0.41) | MTNR1AMTNR1BPDE10ACYP3A4CYP2D6 | |
| SCHEMBL11979709 | 0.79 | CYP19A1 (0.48) | PDE10A | |
| SCHEMBL11979711 | 0.79 | PDE10A (0.39) | PDE10ACYP3A4CYP2D6CYP1A2MAPT | |
| SCHEMBL4568577 | 0.78 | MTNR1A (0.48) | MTNR1AMTNR1BMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |
| US-8815903-B2 | Indole derivative and pharmacologically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | disclosed |