Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.39 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533077 | 0.95 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CGHTR2C | |
| SCHEMBL15975808 | 0.86 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL533078 | 0.85 | PIK3CA (0.46) | PIK3CAPIK3CDPIK3CBPIK3CGHTR2C | |
| SCHEMBL15975815 | 0.81 | PIK3CA (0.53) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL532283 | 0.81 | PIK3CA (0.67) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL532071 | 0.78 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL15976340 | 0.77 | PIK3CA (0.51) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL532165 | 0.76 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL532397 | 0.76 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL532475 | 0.72 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |