SCHEMBL1597664

SCHEMBL1597664

COC(=O)c1cc(-c2ccc(N)cc2)oc1C

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.50
NPC1 O15118 4/20 0.50
ALDH1A1 P00352 8/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
KDM4E B2RXH2 3/20 0.49
HSD17B10 Q99714 3/20 0.49
MAPK1 P28482 1/20 0.49
GAA P10253 3/20 0.47
MAPT P10636 6/20 0.46
HPGD P15428 5/20 0.46
APP P05067 1/20 0.44
POLB P06746 1/20 0.42
TP53 P04637 2/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MEN1 O00255 2/20 0.41
CYP1A2 P05177 2/20 0.41
KMT2A Q03164 2/20 0.41
L3MBTL1 Q9Y468 2/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4704556 0.85 RAB9A (0.56) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3091048 0.85 SLC6A4 (0.51) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3102333 0.85 ALDH1A1 (0.62) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3914366 0.85 NPC1 (0.70) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL2665747 0.84 ALDH1A1 (0.61) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL4184070 0.82 ALDH1A1 (0.44) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3101093 0.81 CFTR (0.50) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3099900 0.80 SCN10A (0.54) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL12876531 0.78 ALDH1A1 (0.48) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E
SCHEMBL3101392 0.76 HDAC6 (0.52) RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103230389-A Novel nitrocatechol derivatives having selectin ligand activity REVOTAR BIOPHARMACEUTICALS AG 2013-08-07 CN disclosed
US-8461207-B2 Phloroglucinol derivatives having selectin ligand activity REVOTAR BIOPHARMACEUTICALS AG (DE) 2013-06-11 US disclosed
US-8461207-B2 Phloroglucinol derivatives having selectin ligand activity REVOTAR BIOPHARMACEUTICALS AG (DE) 2013-06-11 US disclosed
CN-101374508-B Novel nitrocatechol derivatives having selectin ligand activity REVOTAR BIOPHARMACEUTICALS AG 2013-04-24 CN disclosed
EP-1948146-B1 NOVEL MULTI-CYCLIC COMPOUNDS AND THEIR USE REVOTAR BIOPHARMACEUTICALS AG (DE) 2012-11-07 EP disclosed
EP-1948146-B1 NOVEL MULTI-CYCLIC COMPOUNDS AND THEIR USE REVOTAR BIOPHARMACEUTICALS AG (DE) 2012-11-07 EP disclosed
US-8278356-B2 2012-10-02 US disclosed
US-8278356-B2 2012-10-02 US disclosed
CN-101267811-B Novel multi-cyclic compounds and their use REVOTAR BIOPHARMACEUTICALS AG 2012-07-25 CN disclosed
US-20110152291-A1 NOVEL AROMATIC COMPOUNDS AND THEIR USE IN MEDICAL APPLICATIONS REVOTAR BIOPHARMACEUTICALS AG (DE) 2011-06-23 US disclosed
EP-1948146-A2 NOVEL MULTI-CYCLIC COMPOUNDS AND THEIR USE Revotar Biopharmaceuticals AG (DE) 2008-07-30 EP disclosed
EP-1937238-A1 NOVEL NITROCATECHOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY Revotar Biopharmaceuticals AG (DE) 2008-07-02 EP disclosed
EP-1937237-A1 NOVEL PHLOROGLUCINOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY Revotar Biopharmaceuticals AG (DE) 2008-07-02 EP disclosed
WO-2007039114-A1 NOVEL NITROCATECHOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY REVOTAR BIOPHARMACEUTICALS AG (DE) 2007-04-12 WO disclosed
WO-2007039114-A1 NOVEL NITROCATECHOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY REVOTAR BIOPHARMACEUTICALS AG (DE) 2007-04-12 WO disclosed
WO-2007039112-A1 NOVEL PHLOROGLUCINOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY REVOTAR BIOPHARMACEUTICALS AG (DE) 2007-04-12 WO disclosed
WO-2007039112-A1 NOVEL PHLOROGLUCINOL DERIVATIVES HAVING SELECTIN LIGAND ACTIVITY REVOTAR BIOPHARMACEUTICALS AG (DE) 2007-04-12 WO disclosed
WO-2007039111-A2 NOVEL MULTI-CYCLIC COMPOUNDS AND THEIR USE REVOTAR BIOPHARMACEUTICALS AG (DE) 2007-04-12 WO disclosed
WO-2007039111-A2 NOVEL MULTI-CYCLIC COMPOUNDS AND THEIR USE REVOTAR BIOPHARMACEUTICALS AG (DE) 2007-04-12 WO disclosed
EP-1764093-A1 Novel aromatic compounds and their use in medical applications Revotar Biopharmaceuticals AG (DE) 2007-03-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152291-A1 NOVEL AROMATIC COMPOUNDS AND THEIR USE IN MEDICAL APPLICATIONS SELP, SELL, SELE RAB9A 3490/4885NPC1 1018/4885ALDH1A1 328/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.