SCHEMBL15977331

SCHEMBL15977331

CC(=O)C1C(c2ccc(C)cc2)C1(Cl)Cl

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.48
HTT P42858 4/20 0.48
HPGD P15428 1/20 0.48
MEN1 O00255 6/20 0.46
KMT2A Q03164 6/20 0.46
ALDH1A1 P00352 3/20 0.46
RECQL P46063 1/20 0.46
MAPT P10636 2/20 0.42
MAPK1 P28482 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
CES2 O00748 2/20 0.38
CES1 P23141 2/20 0.38
NPSR1 Q6W5P4 1/20 0.37
CCR1 P32246 1/20 0.36
CCR2 P41597 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21021146 0.80 HTT (0.45) LMNAHTTHPGDMEN1KMT2A
SCHEMBL21020726 0.79 SLC9A1 (0.43) LMNAHTTHPGDMEN1KMT2A
SCHEMBL21021529 0.79 MEN1 (0.58) LMNAHTTHPGDMEN1KMT2A
SCHEMBL15977341 0.79 CHRNA1 (0.42) LMNAHTTHPGDMEN1KMT2A
SCHEMBL15977340 0.78 SLC9A1 (0.44) LMNAALDH1A1MAPTCYP1A2CYP3A4
SCHEMBL21022296 0.77 NPSR1 (0.44) LMNAHTTHPGDMEN1KMT2A
SCHEMBL20076620 0.76 SLC9A1 (0.40) LMNAHTTMEN1KMT2AALDH1A1
SCHEMBL21021442 0.75 SLC9A1 (0.56) LMNAHTTHPGDMEN1KMT2A
SCHEMBL21021644 0.73 ADRA2A (0.39) LMNAMEN1KMT2AALDH1A1RECQL
SCHEMBL11474646 0.72 SLC9A1 (0.41) LMNAHTTHPGDALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170247725-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-08-31 US disclosed
US-9493799-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-11-15 US disclosed
US-20160032330-A1 P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-02-04 US disclosed
US-20160002682-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES UNITED STATES DEPARTMENT OF ENERGY 2016-01-07 US disclosed
US-8993262-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-03-31 US disclosed
US-20140242647-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2014-08-28 US disclosed