SCHEMBL15977340

SCHEMBL15977340

CC(=O)C1C(c2ccc(C)cc2)C1(C)C

nearest known ligand 0.44

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC9A1 P19634 8/20 0.44
ALDH1A1 P00352 4/20 0.38
LMNA P02545 3/20 0.38
CES2 O00748 2/20 0.37
CES1 P23141 2/20 0.37
TDP1 Q9NUW8 1/20 0.36
GAA P10253 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
MAPT P10636 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3287373 0.86 SLC9A1 (0.46) SLC9A1ALDH1A1LMNACES2CES1
SCHEMBL3287377 0.86 SLC9A1 (0.46) SLC9A1ALDH1A1LMNACES2CES1
SCHEMBL3287385 0.86 SLC9A1 (0.46) SLC9A1ALDH1A1LMNACES2CES1
SCHEMBL11474646 0.85 SLC9A1 (0.41) SLC9A1ALDH1A1LMNACES2CES1
Hydrochloric Acid SCHEMBL11474654 0.85 SLC9A1 (0.45) SLC9A1ALDH1A1LMNACES2CES1
SCHEMBL17772002 0.84 SLC9A1 (0.45) SLC9A1LMNAGAASMN1; SMN2MAPT
SCHEMBL19398555 0.82 MEN1 (0.45) SLC9A1LMNATDP1SMN1; SMN2
SCHEMBL18927360 0.82 SLC9A1 (0.62) SLC9A1ALDH1A1LMNASMN1; SMN2MAPT
SCHEMBL15977331 0.78 LMNA (0.48) ALDH1A1LMNACES2CES1MAPT
SCHEMBL17414154 0.78 CHRNA1 (0.43) SLC9A1ALDH1A1LMNAGAASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170247725-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2017-08-31 US disclosed
US-9493799-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-11-15 US disclosed
US-20160032330-A1 P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2016-02-04 US disclosed
US-20160002682-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES UNITED STATES DEPARTMENT OF ENERGY 2016-01-07 US disclosed
US-8993262-B2 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2015-03-31 US disclosed
US-20140242647-A1 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES CALIFORNIA INSTITUTE OF TECHNOLOGY (US) 2014-08-28 US disclosed