Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 16/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL797342 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL29894730 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL24423111 | 0.84 | ALDH1A1 (0.71) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL29692810 | 0.82 | ALDH1A1 (0.60) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL2206344 | 0.82 | ALDH1A1 (0.60) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL30426206 | 0.82 | ALDH1A1 (0.59) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL18526865 | 0.81 | ALDH1A1 (0.67) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL12786989 | 0.80 | ALDH1A1 (0.75) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL5739160 | 0.78 | ALDH1A1 (1.00) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 | |
| SCHEMBL15555582 | 0.76 | ALDH1A1 (0.75) | ALDH1A1TSHRHSD17B10MAPK1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243302-A1 | BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME CORPORATION (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243302-A1 | BRIDGED BICYCLIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS | PAICS, SBDS, SORD | ALDH1A1 802/4885TSHR 4681/4885HSD17B10 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.