Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL3639963 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL3633829 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21569386 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29587574 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1291555 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL42945 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL22686437 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL23012792 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20668547 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL9754280 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 861 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636311-B2 | Topically administered strontium-containing complexes for treating pain, pruritis and inflammation | GALLEON LABS LLC (US) | 2026-05-26 | — | — | US | claimed |
| US-12350120-B1 | Gum-protecting and teeth-whitening strip and preparation method thereof | Jiangxi Dentalbright Technology Co., Ltd. (CN) | 2025-07-08 | — | — | US | claimed |
| US-12350353-B2 | Synthetic enamel and uses thereof | TRUSTEES OF BOSTON UNIVERSITY (US) | 2025-07-08 | — | — | US | claimed |
| US-20250099498-A1 | STRONTIUM BASED COMPOSITIONS AND FORMULATIONS FOR PAIN, PRURITUS, AND INFLAMMATION | GALLEON LABS LLC (US) | 2025-03-27 | — | — | US | claimed |
| US-12257553-B2 | Separation membrane and methods of preparation thereof | ASPEN PRODUCTS GROUP, INC. (US) | 2025-03-25 | — | — | US | claimed |
| CN-119505190-A | Metal ion hybridized degradable polyester, and preparation method and application thereof | 广东粤港澳大湾区黄埔材料研究院 | 2025-02-25 | — | — | CN | claimed |
| CN-119454516-A | Gum protecting and whitening tooth paste and preparation method thereof | 江西登特科技有限公司 | 2025-02-18 | — | — | CN | claimed |
| CN-119214942-A | Residue-free whitening tooth paste and preparation method thereof | 江西登特科技有限公司 | 2024-12-31 | — | — | CN | claimed |
| CN-119061118-A | DNA extraction method for jeans detection material containing trace DNA | 宁波市博坤生物科技有限公司 | 2024-12-03 | — | — | CN | claimed |
| CN-118947470-A | Making method of rice and wheat flour rich in strontium element | 黄西军 | 2024-11-15 | — | — | CN | claimed |
| EP-1419760-A1 | Antiperspirant compositions of enhanced efficacy containing strontium | REHEIS, INC. (US) | 2004-05-19 | — | — | EP | claimed |
| US-20040091436-A1 | Antiperspirant compositions of enhanced efficacy containing strontium | REHEIS, INC. | 2004-05-13 | — | — | US | claimed |
| CN-1136856-C | Use of strontium salts for production of pharmaceutical compositions intended for treatment of arthrosis | ɪά��ʵ���� | 2004-02-04 | — | — | CN | claimed |
| CN-1322484-A | Animal nutrient | YANG SHUANMING (CN) | 2001-11-21 | — | — | CN | claimed |
| EP-0416321-B1 | Crystalline polyolefin composition | CHISSO CORP (JP) | 1994-11-09 | — | — | EP | claimed |
| US-5330746-A | Sustained release of bactericide, acrylic polymer carrier | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1994-07-19 | — | — | US | claimed |
| US-5160737-A | Acrylic copolymer; sustained release; dentistry, dermatology | PERIO PRODUCTS LTD. (IL) | 1992-11-03 | — | — | US | claimed |
| US-5063264-A | Molding materials | CHISSO CORPORATION (JP) | 1991-11-05 | — | — | US | claimed |
| EP-0416321-A1 | Crystalline polyolefin composition | Chisso Corporation (JP) | 1991-03-13 | — | — | EP | claimed |
| EP-0404558-A1 | Liquid polymer composition, and method of use | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1990-12-27 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12636311-B2 | Topically administered strontium-containing complexes for treating pain, pruritis and inflammation | SUCNR1, TRPV1, TRPV2 | CA4 559/4885ALDH1A1 1432/4885CASP1 1492/4885 |
| US-12350120-B1 | Gum-protecting and teeth-whitening strip and preparation method thereof | TAS2R30, TAS2R60, TAS2R14 | CA4 4495/4885ALDH1A1 1780/4885CASP1 2630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.