Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740665 | 0.95 | MAPT (0.72) | MAPTTSHRHSD17B10HPGDALDH1A1 | |
| SCHEMBL5462361 | 0.86 | MAPT (0.64) | MAPTTSHRHSD17B10HPGDALDH1A1 | |
| SCHEMBL5481793 | 0.84 | MAPT (0.60) | MAPTTSHRHSD17B10HPGDALDH1A1 | |
| SCHEMBL3381659 | 0.83 | TDP1 (0.49) | MAPTTSHRALDH1A1NPSR1KDM4E | |
| SCHEMBL30419970 | 0.83 | TDP1 (0.49) | MAPTTSHRALDH1A1NPSR1KDM4E | |
| SCHEMBL16003471 | 0.81 | ALDH1A1 (0.45) | MAPTHSD17B10ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL5278989 | 0.81 | SMN1; SMN2 (0.44) | MAPTHPGDALDH1A1NPSR1KDM4E | |
| SCHEMBL5239456 | 0.81 | MAPT (0.42) | MAPTTSHRALDH1A1NPSR1KDM4E | |
| SCHEMBL30871973 | 0.81 | ALDH1A1 (0.45) | MAPTHSD17B10ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL6202561 | 0.81 | MAPT (0.42) | MAPTHSD17B10ALDH1A1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014134308-A1 | SUBSTITUTED 7-OXO-PYRIDO [2, 3-D] PYRIMIDINES AND THEIR USE FOR THE TREATMENT OF EGFR / ERBB2 RELATED DISORDERS | AMGEN INC. (US) | 2014-09-04 | — | — | WO | disclosed |