Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2502259 | 0.82 | MAPT (0.62) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL16003231 | 0.81 | MAPT (0.66) | MAPTALDH1A1KDM4ECYP3A4HSD17B10 | |
| SCHEMBL3381659 | 0.79 | TDP1 (0.49) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL30419970 | 0.79 | TDP1 (0.49) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL9694281 | 0.78 | ALDH3A1 (0.56) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL5278989 | 0.77 | SMN1; SMN2 (0.44) | MAPTALDH1A1KDM4EALOX15MEN1 | |
| SCHEMBL16003471 | 0.77 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL5239456 | 0.77 | MAPT (0.42) | MAPTALDH1A1KDM4ECYP3A4PTGS2 | |
| SCHEMBL30871973 | 0.77 | ALDH1A1 (0.45) | MAPTALDH1A1KDM4ECYP3A4ALOX15 | |
| SCHEMBL4313460 | 0.76 | ALDH1A1 (0.52) | MAPTALDH1A1KDM4ECYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1266887-B1 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2005-08-17 | — | — | EP | disclosed |
| US-6627650-B2 | An isomer thereof, or an addition salt thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti- cancer agents. | LES LABORATOIRES SERVIER (FR) | 2003-09-30 | — | — | US | disclosed |
| EP-1266887-A2 | Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2002-12-18 | — | — | EP | disclosed |