Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16003471 | 1.00 | ALDH1A1 (0.45) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL3719769 | 0.87 | ALDH1A1 (0.52) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL3312562 | 0.85 | SMN1; SMN2 (0.47) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL3314688 | 0.85 | LMNA (0.42) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL16003397 | 0.84 | MAPT (0.38) | ALDH1A1TDP1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3311685 | 0.83 | LMNA (0.41) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL23653979 | 0.83 | ALDH1A1 (0.40) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL15994474 | 0.82 | ALDH1A1 (0.40) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL222267 | 0.82 | MAPT (0.62) | ALDH1A1TDP1LMNASIRT6MAPT | |
| SCHEMBL15994627 | 0.81 | ALDH1A1 (0.53) | ALDH1A1LMNASIRT6MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240409609-A1 | REVERSIBLE LYSINE COVALENT MODIFIERS OF EGFR AND USES THEREOF | TERREMOTO BIOSCIENCES, INC. | 2024-12-12 | — | — | US | disclosed |
| CN-111825658-B | EGFR three-mutation inhibitor and application thereof | 华东理工大学 | 2024-11-08 | — | — | CN | disclosed |
| CN-117794914-A | Pyrimidine-2, 4-diamine derivatives, process for preparing the same, and pharmaceutical composition for preventing or treating cancer comprising the same as active ingredient | 韩国化学研究院 | 2024-03-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240409609-A1 | REVERSIBLE LYSINE COVALENT MODIFIERS OF EGFR AND USES THEREOF | EGFR, ERBB2, ERBB3 | ALDH1A1 3648/4885TDP1 2063/4885LMNA 3678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.