Sugi Predict

Sugi Predict / Compounds / SCHEMBL1600377

SCHEMBL1600377

SCHEMBL1600377

COC1(c2ccc(C(F)(F)F)cc2CNCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CCCCCC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TACR1 P25103 4/20 0.42
▸ GPBAR1 Q8TDU6 2/20 0.38
▸ MTOR P42345 1/20 0.35
▸ DPP7 Q9UHL4 1/20 0.34
▸ SLC6A4 P31645 2/20 0.34
▸ SLC6A3 Q01959 2/20 0.34
▸ RHOC P08134 1/20 0.34
▸ RHOA P61586 1/20 0.34
▸ CYP3A4 P08684 2/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ PPARD Q03181 1/20 0.33
▸ PPARA Q07869 1/20 0.33
▸ CETP P11597 1/20 0.33
▸ CCR2 P41597 2/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ HTT P42858 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3949919 0.79 SLC6A4 (0.36) TACR1SLC6A4SLC6A3CETP
SCHEMBL1601207 0.79 SLC6A4 (0.36) TACR1SLC6A4SLC6A3CETP
SCHEMBL1599512 0.79 ALOX15 (0.39) SLC6A4SLC6A3CETP
SCHEMBL1600303 0.79 ALOX15 (0.39) SLC6A4SLC6A3CETP
SCHEMBL1601202 0.78 ALOX15 (0.40) SLC6A4SLC6A3CETP
SCHEMBL1600369 0.78 SLC6A4 (0.34) SLC6A4SLC6A3
Benzene SCHEMBL28081456 0.77 SLC6A4 (0.37) TACR1SLC6A4SLC6A3CYP3A4SMN1; SMN2
SCHEMBL1601283 0.75 MAPT (0.38) TACR1SLC6A4SLC6A3SMN1; SMN2CETP
SCHEMBL14414188 0.74 CETP (0.40) CETP
SCHEMBL1601211 0.73 CETP (0.39) TACR1CETPALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7919506-B2 Dibenzyl amine compounds and derivatives PFIZER INC. (US) 2011-04-05 — — US disclosed
US-7919506-B2 Dibenzyl amine compounds and derivatives PFIZER INC. (US) 2011-04-05 — — US disclosed
US-7919506-B2 Dibenzyl amine compounds and derivatives PFIZER INC. (US) 2011-04-05 — — US disclosed
EP-1996564-A1 DIBENZYL AMINE COMPOUNDS AND DERIVATIVES Pfizer Products Incorporated (US) 2008-12-03 — — EP disclosed
WO-2007105050-A1 DIBENZYL AMINE COMPOUNDS AND DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-09-20 — — WO disclosed
WO-2007105050-A1 DIBENZYL AMINE COMPOUNDS AND DERIVATIVES PFIZER PRODUCTS INC. (US) 2007-09-20 — — WO disclosed
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives PFIZER INC 2007-09-13 — — US disclosed
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives PFIZER INC 2007-09-13 — — US disclosed
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives PFIZER INC 2007-09-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070213371-A1 Dibenzyl Amine Compounds and Derivatives APOB, LDLR, CETP TACR1 2334/4885GPBAR1 46/4885MTOR 2035/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.