Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RBP4 | P02753 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TET3 | O43151 | 2/20 | 0.37 |
| ▸ | FBXL19 | Q6PCT2 | 2/20 | 0.37 |
| ▸ | CXXC5 | Q7LFL8 | 2/20 | 0.37 |
| ▸ | TET1 | Q8NFU7 | 2/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.37 |
| ▸ | CXXC4 | Q9H2H0 | 2/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874783 | 0.76 | DRD2 (0.53) | ADRA1AADRA1DADRA1BADRB1KMT2A | |
| SCHEMBL4873768 | 0.70 | SOAT1 (0.55) | ADRA1AADRA1DADRA1BKMT2AHTR1A | |
| SCHEMBL22949523 | 0.69 | HPGD (0.47) | — | |
| SCHEMBL4880864 | 0.68 | DRD2 (0.52) | ADRA1AADRA1DADRA1BKMT2AHTR1A | |
| SCHEMBL1600115 | 0.67 | KMT2A (0.47) | KMT2A | |
| SCHEMBL4878235 | 0.67 | SOAT1 (0.52) | ADRA1AADRA1DADRA1BKMT2AHTR1A | |
| SCHEMBL4881137 | 0.65 | CA12 (0.49) | ADRA1AADRA1DADRA1BKMT2AHTR1A | |
| SCHEMBL16979517 | 0.65 | OPRM1 (0.62) | CHRM1ADRA1AKMT2ATET3FBXL19 | |
| SCHEMBL972474 | 0.65 | TSHR (0.65) | HSD17B10KMT2ATET3FBXL19CXXC5 | |
| SCHEMBL5476169 | 0.65 | SOAT1 (0.55) | ADRA1AADRA1DADRA1BKMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919617-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7897599-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-03-01 | — | — | US | disclosed |