Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 9/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 3/20 | 0.39 |
| ▸ | STAT1 | P42224 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1600053 | 0.75 | SCN9A (0.36) | KMT2AALDH1A1SCN9AMAP3K14RORC | |
| SCHEMBL9025523 | 0.72 | RORC (0.56) | KMT2AALDH1A1SCN9ARORCSTAT1 | |
| SCHEMBL5652361 | 0.69 | PDE10A (0.48) | KMT2AALDH1A1RORCSTAT1MEN1 | |
| SCHEMBL22949523 | 0.69 | HPGD (0.47) | ALDH1A1 | |
| SCHEMBL9024249 | 0.68 | ALDH1A1 (0.57) | ALDH1A1SCN9ARORCBCL2STAT1 | |
| SCHEMBL1600387 | 0.67 | CHRM5 (0.41) | KMT2A | |
| SCHEMBL27712242 | 0.66 | F12 (0.59) | KMT2A | |
| SCHEMBL27732440 | 0.65 | ELANE (0.56) | KMT2AALDH1A1MEN1 | |
| SCHEMBL28774901 | 0.65 | ELANE (0.56) | KMT2AMEN1PKM | |
| SCHEMBL7421574 | 0.65 | SCN9A (0.58) | ALDH1A1SCN9ARORCSTAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919617-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7897599-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-03-01 | — | — | US | disclosed |