Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | GPR142 | Q7Z601 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16004118 | 0.83 | PIK3CA (0.47) | RIPK1PIK3CAGPR142 | |
| SCHEMBL16004128 | 0.81 | PIK3CA (0.49) | RIPK1PIK3CACREBBP | |
| SCHEMBL16004291 | 0.80 | MAPT (0.47) | RIPK1NPC1RAB9APOLBCREBBP | |
| SCHEMBL16004069 | 0.80 | GPR142 (0.59) | RIPK1NPC1RAB9ACREBBPGPR142 | |
| SCHEMBL16004060 | 0.79 | LMNA (0.43) | RIPK1PIK3CANPC1BCL2GPR142 | |
| SCHEMBL16003965 | 0.77 | CHRM5 (0.40) | RIPK1POLBCHRM5 | |
| SCHEMBL16004307 | 0.77 | PIK3CA (0.40) | RIPK1PIK3CANPC1RAB9AHSP90AA1 | |
| SCHEMBL16004052 | 0.76 | PIK3CA (0.52) | RIPK1PIK3CA | |
| SCHEMBL16004102 | 0.76 | PIK3CA (0.41) | RIPK1PIK3CANPC1RAB9AHSP90AA1 | |
| SCHEMBL16004082 | 0.75 | MC4R (0.38) | RIPK1POLBCHRM5GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014133414-A2 | HETEROCYCLIC TGR5 BILE ACID RECEPTOR AGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ ЛЛС (US) | 2014-09-04 | — | — | WO | disclosed |