Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406512 | 0.91 | HPGD (0.79) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL5037684 | 0.86 | HPGD (0.52) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL2566192 | 0.84 | HPGD (0.69) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL29386132 | 0.84 | HPGD (0.69) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL2854780 | 0.82 | HPGD (0.67) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL5432092 | 0.82 | HPGD (0.77) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL11506268 | 0.81 | HPGD (0.77) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| Diethyltoluamide SCHEMBL29976 | 0.80 | HPGD (1.00) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL1867393 | 0.80 | HPGD (0.69) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 | |
| Diethyltoluamide SCHEMBL29374310 | 0.80 | HPGD (1.00) | HPGDTDP1ALDH1A1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2774926-B1 | MORPHINAN DERIVATIVE | THE KITASATO INST (JP) | 2017-03-15 | — | — | EP | disclosed |
| US-8952030-B2 | Morphinan derivative | THE KITASATO INSTITUTE (JP) | 2015-02-10 | — | — | US | disclosed |
| US-20140343015-A1 | MORPHINAN DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 2014-11-20 | — | — | US | disclosed |
| EP-2774926-A1 | MORPHINAN DERIVATIVE | The Kitasato Institute (JP) | 2014-09-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343015-A1 | MORPHINAN DERIVATIVE | ATXN10, OPRM1, OPRL1 | HPGD 3755/4885TDP1 4835/4885ALDH1A1 2078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.