SCHEMBL16007166

SCHEMBL16007166

COC(=O)c1c(NC(=O)c2ccc(Cl)nc2NC2CCN(CCO)CC2)sc2c1CCNC2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 2/20 0.39
KMT2A Q03164 2/20 0.39
MYC P01106 1/20 0.38
ALDH1A1 P00352 4/20 0.38
KDM4E B2RXH2 3/20 0.38
HPGD P15428 3/20 0.38
GAA P10253 1/20 0.38
HIF1A Q16665 1/20 0.38
TLR2 O60603 2/20 0.37
TP53 P04637 4/20 0.37
CXCR2 P25025 1/20 0.36
MAPT P10636 4/20 0.36
POLB P06746 3/20 0.36
HSD17B10 Q99714 3/20 0.36
TDP1 Q9NUW8 2/20 0.36
NPC1 O15118 1/20 0.36
USP2 O75604 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MAPK1 P28482 1/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16007649 0.90 SLC6A12 (0.44) KMT2AALDH1A1KDM4ETLR2TP53
SCHEMBL16007789 0.88 TP53 (0.41) RAB9AKMT2AMYCALDH1A1KDM4E
SCHEMBL16007586 0.88 RORC (0.37) RAB9AKMT2AMYCALDH1A1KDM4E
SCHEMBL16007620 0.83 TLR2 (0.39) RAB9AKMT2AALDH1A1KDM4EHPGD
SCHEMBL16007494 0.80 RORC (0.46) ALDH1A1KDM4EHPGDTLR2TP53
SCHEMBL16017760 0.79 RORC (0.46) ALDH1A1KDM4ETP53CXCR2HSD17B10
SCHEMBL16017808 0.74 ALDH1A1 (0.45) KMT2AALDH1A1KDM4EGAATP53
SCHEMBL16007500 0.73 RORC (0.44) ALDH1A1KDM4EHPGDTLR2TP53
SCHEMBL16007621 0.73 RORC (0.44) ALDH1A1KDM4ETLR2TP53CXCR2
SCHEMBL16017761 0.71 NPSR1 (0.49) RAB9AALDH1A1GAATP53POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9227955-B2 Compound having angiogenesis inhibitory activity, method for preparing same, and pharmaceutical composition comprising same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2016-01-05 US claimed
US-20140256711-A1 Novel Compound Having Angiogenesis Inhibitory Activity, Method for Preparing Same, and Pharmaceutical Composition Comprising Same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2014-09-11 US claimed
US-9227955-B2 Compound having angiogenesis inhibitory activity, method for preparing same, and pharmaceutical composition comprising same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2016-01-05 US disclosed
US-9227955-B2 Compound having angiogenesis inhibitory activity, method for preparing same, and pharmaceutical composition comprising same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2016-01-05 US disclosed
US-9227955-B2 Compound having angiogenesis inhibitory activity, method for preparing same, and pharmaceutical composition comprising same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2016-01-05 US disclosed
US-20140256711-A1 Novel Compound Having Angiogenesis Inhibitory Activity, Method for Preparing Same, and Pharmaceutical Composition Comprising Same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2014-09-11 US disclosed
US-20140256711-A1 Novel Compound Having Angiogenesis Inhibitory Activity, Method for Preparing Same, and Pharmaceutical Composition Comprising Same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2014-09-11 US disclosed
US-20140256711-A1 Novel Compound Having Angiogenesis Inhibitory Activity, Method for Preparing Same, and Pharmaceutical Composition Comprising Same BORYUNG PHARMACEUTICAL CO., LTD. (KR) 2014-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140256711-A1 Novel Compound Having Angiogenesis Inhibitory Activity, Method for Preparing Same, and Pharmaceutical Composition Comprising Same VEGFA, EDF1, FLT1 RAB9A 743/4885KMT2A 4447/4885MYC 4755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.