Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | TSPO | P30536 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876660 | 0.92 | TSHR (0.50) | TSHRUSP2ALDH1A1NPSR1HTT | |
| SCHEMBL14861373 | 0.86 | TDP1 (0.48) | TSHRALDH1A1NPSR1HDAC1HDAC6 | |
| SCHEMBL24851932 | 0.81 | ALDH1A1 (0.44) | TSHRALDH1A1HTTSMN1; SMN2TDP1 | |
| SCHEMBL14865856 | 0.81 | ALDH1A1 (0.48) | TSHRUSP2ALDH1A1NPSR1HTT | |
| SCHEMBL207543 | 0.81 | TSHR (0.53) | TSHRUSP2ALDH1A1NPSR1HTT | |
| SCHEMBL23857640 | 0.80 | MEP1B (0.58) | ALDH1A1NPSR1HTTALOX5SMN1; SMN2 | |
| SCHEMBL18646559 | 0.77 | TSHR (0.62) | TSHRUSP2ALDH1A1NPSR1HTT | |
| SCHEMBL211062 | 0.76 | TSHR (0.51) | TSHRUSP2ALDH1A1NPSR1HTT | |
| SCHEMBL6121816 | 0.76 | TSHR (0.73) | TSHRUSP2ALDH1A1NPSR1HTT | |
| SCHEMBL14252330 | 0.76 | ALDH1A1 (0.48) | TSHRUSP2ALDH1A1NPSR1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105164127-A | Bromodomain inhibitors | ABBVIE INC | 2015-12-16 | — | — | CN | disclosed |
| US-9050346-B2 | Bromodomain inhibitors | ABBVIE INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20140256705-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256705-A1 | BROMODOMAIN INHIBITORS | BRD4, BRD3, BRD1 | TSHR 2559/4885USP2 1523/4885ALDH1A1 1453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.