Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | TSPO | P30536 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211062 | 0.83 | TSHR (0.51) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL16008426 | 0.81 | TSHR (0.48) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL20472128 | 0.80 | TDP1 (0.54) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL18942071 | 0.78 | ALDH1A1 (0.54) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL14252330 | 0.78 | ALDH1A1 (0.48) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL3484433 | 0.78 | TDP1 (0.60) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL9416611 | 0.76 | TSPO (0.58) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL18646559 | 0.76 | TSHR (0.62) | TSHRUSP2TDP1ALDH1A1HTT | |
| SCHEMBL27035726 | 0.76 | ALDH1A1 (0.52) | TSHRUSP2ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL25143322 | 0.75 | TSHR (0.57) | TSHRUSP2TDP1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088923-B2 | Cyclic-fused beta-lactones and their synthesis | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2012-01-03 | — | — | US | disclosed |
| US-8088923-B2 | Cyclic-fused beta-lactones and their synthesis | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2012-01-03 | — | — | US | disclosed |
| US-20090062547-A1 | CYCLIC-FUSED BETA-LACTONES AND THEIR SYNTHESIS | THE TEXAS A&M UNIVERSITY SYSTEM | 2009-03-05 | — | — | US | disclosed |
| US-20090062547-A1 | CYCLIC-FUSED BETA-LACTONES AND THEIR SYNTHESIS | THE TEXAS A&M UNIVERSITY SYSTEM | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062547-A1 | CYCLIC-FUSED BETA-LACTONES AND THEIR SYNTHESIS | COASY, FASN, OTUB1 | TSHR 4563/4885USP2 94/4885TDP1 4229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.