Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.58 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 10/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | TLR2 | O60603 | 1/20 | 0.52 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25021708 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| SCHEMBL1197466 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| SCHEMBL13794162 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| SCHEMBL14544486 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| SCHEMBL862934 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| Hydrochloric Acid SCHEMBL28254537 | 0.98 | SMN1; SMN2 (0.96) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| SCHEMBL12539724 | 0.86 | SMN1; SMN2 (0.76) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| SCHEMBL12539722 | 0.86 | SMN1; SMN2 (0.76) | SMN1; SMN2NPSR1MTNR1AMTNR1BKDM1A | |
| SCHEMBL6154005 | 0.85 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1KDM1ACNR1HRH3 | |
| SCHEMBL7980208 | 0.85 | SMN1; SMN2 (0.73) | SMN1; SMN2NPSR1KDM1ACNR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230051773-A1 | TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | AXIAL THERAPEUTICS, INC. (US) | 2023-02-16 | — | — | US | disclosed |
| US-7919617-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-04-05 | — | — | US | disclosed |
| US-7897599-B2 | Cytokine inhibitors | iTherX Pharmaceuticals Inc. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20100273797-A1 | ALPHA-KETOAMIDES AND DERIVATIVES THEREOF | ITHERX PHARMACEUTICALS, INC. | 2010-10-28 | — | — | US | disclosed |
| US-7749999-B2 | Alpha-ketoamides and derivatives thereof | ITHERX PHARMACEUTICALS, INC. (US) | 2010-07-06 | — | — | US | disclosed |
| US-20100093734-A1 | CYTOKINE INHIBITORS | ITHERX PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20100093735-A1 | CYTOKINE INHIBITORS | ITHERX PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | US | disclosed |
| US-20050107399-A1 | Cytokine inhibitors | KEMIA, INC. | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107399-A1 | Cytokine inhibitors | TNF, IL1RN, IL1A | SMN1; SMN2 4806/4885NPSR1 2141/4885MTNR1A 844/4885 |
| US-20230051773-A1 | TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | TLR2, TLR3, TLR4 | SMN1; SMN2 4036/4885NPSR1 854/4885MTNR1A 337/4885 |
| US-20100093734-A1 | CYTOKINE INHIBITORS | TNF, IL1RN, IL1A | SMN1; SMN2 4806/4885NPSR1 2141/4885MTNR1A 844/4885 |
| US-20100273797-A1 | ALPHA-KETOAMIDES AND DERIVATIVES THEREOF | TNF, IL1A, IL1B | SMN1; SMN2 4623/4885NPSR1 1491/4885MTNR1A 1529/4885 |
| US-20100093735-A1 | CYTOKINE INHIBITORS | TNF, IL1RN, IL1A | SMN1; SMN2 4806/4885NPSR1 2141/4885MTNR1A 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.